Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20945667 | 0.91 | LMNA (0.43) | ALDH1A1KMT2AMAPTHPGDSTING1 | |
| SCHEMBL30666368 | 0.82 | SMN1; SMN2 (0.49) | ALDH1A1KMT2AHPGDSTING1CYP3A4 | |
| SCHEMBL979632 | 0.81 | NPC1 (0.47) | ALDH1A1KMT2AHPGDCYP1A2CYP3A4 | |
| SCHEMBL670880 | 0.79 | CA12 (0.55) | ALDH1A1KMT2AMAPTCYP1A2CYP3A4 | |
| SCHEMBL5313798 | 0.79 | NPC1 (0.57) | ALDH1A1KMT2AMAPTHPGDLMNA | |
| SCHEMBL1376927 | 0.78 | SMN1; SMN2 (0.44) | ALDH1A1KMT2AMAPTSTING1CYP1A2 | |
| SCHEMBL4686898 | 0.78 | LMNA (0.61) | ALDH1A1KMT2AMAPTHPGDCYP1A2 | |
| SCHEMBL10456907 | 0.78 | KMT2A (0.68) | ALDH1A1KMT2AMAPTHPGDCYP1A2 | |
| SCHEMBL4315127 | 0.77 | ALDH1A1 (0.45) | ALDH1A1KMT2AMAPTHPGDSTING1 | |
| SCHEMBL30666326 | 0.77 | RXFP1 (0.51) | ALDH1A1KMT2AMAPTHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612243-B2 | Cyclopenta[b]naphthalene derivatives | MERCK PATENT GMBH (DE) | 2009-11-03 | — | — | US | disclosed |
| US-7612243-B2 | Cyclopenta[b]naphthalene derivatives | MERCK PATENT GMBH (DE) | 2009-11-03 | — | — | US | disclosed |
| US-20080058537-A1 | CYCLOPENTA[B]NAPHTHALENE DERIVATIVES | LIETZAU LARS | 2008-03-06 | — | — | US | disclosed |
| US-20080058537-A1 | CYCLOPENTA[B]NAPHTHALENE DERIVATIVES | LIETZAU LARS | 2008-03-06 | — | — | US | disclosed |
| US-7291366-B2 | Cyclopenta[b]naphthalene derivatives | MERCK PATENT GMBH (DE) | 2007-11-06 | — | — | US | disclosed |
| US-7291366-B2 | Cyclopenta[b]naphthalene derivatives | MERCK PATENT GMBH (DE) | 2007-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058537-A1 | CYCLOPENTA[B]NAPHTHALENE DERIVATIVES | NUCB2, NDC1, JUP | ALDH1A1 3989/4885KMT2A 4706/4885MAPT 654/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.