Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | TDO2 | P48775 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12631776 | 0.77 | HSD17B1 (0.49) | LIMK1MAP4K4CYP3A4CYP2C9ADORA1 | |
| SCHEMBL13616809 | 0.77 | DHFR (0.47) | TDO2LIMK1MAP4K4IKBKEADORA2A | |
| SCHEMBL13616808 | 0.77 | ALDH1A1 (0.46) | ALDH1A1LIMK1MAP4K4ABL1NTRK1 | |
| SCHEMBL13616946 | 0.76 | ADORA2A (0.40) | KDM4EALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL926914 | 0.76 | KDM4E (0.55) | KDM4ETDO2ALDH1A1MAPTCYP1A2 | |
| SCHEMBL15692562 | 0.75 | KDM4E (0.50) | KDM4ETDO2ALDH1A1MAPTCYP1A2 | |
| SCHEMBL9835729 | 0.74 | KDM4E (0.58) | KDM4EALDH1A1PDPK1 | |
| SCHEMBL27217226 | 0.74 | KDM4E (0.53) | KDM4ETDO2ALDH1A1MAPTCYP1A2 | |
| SCHEMBL679793 | 0.74 | KDM4E (0.53) | KDM4EALDH1A1MAPTLIMK1MEN1 | |
| SCHEMBL2097336 | 0.74 | KDM4E (0.53) | KDM4ETDO2ALDH1A1MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119716-A1 | AZA-BRIDGED-RING COMPOUND | Astellas Pharma Inc. (JP) | 2009-11-18 | — | — | EP | disclosed |