Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2094685 | 0.82 | MEN1 (0.41) | ALDH1A1MEN1KMT2ARAB9AMAP4K4 | |
| SCHEMBL2094681 | 0.79 | RAB9A (0.42) | ALDH1A1MEN1KMT2ARAB9AMAP4K4 | |
| SCHEMBL12631776 | 0.79 | HSD17B1 (0.49) | MAP4K4ADORA1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL13616809 | 0.79 | DHFR (0.47) | MAP4K4ADORA1DPP4LIMK1ADORA2A | |
| SCHEMBL13616783 | 0.77 | KDM4E (0.53) | ALDH1A1MEN1KMT2ARAB9AMAP4K4 | |
| SCHEMBL3890158 | 0.76 | MAPK14 (0.61) | ALDH1A1MEN1KMT2ARAB9AADORA1 | |
| SCHEMBL13616945 | 0.76 | ADORA2A (0.48) | ALDH1A1ADORA1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL1338215 | 0.74 | KDM4E (0.69) | — | |
| SCHEMBL16613002 | 0.74 | KMO (0.42) | ALDH1A1MAPK14CDK5HSD17B10 | |
| SCHEMBL3890922 | 0.72 | MAPK14 (0.60) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119716-A1 | AZA-BRIDGED-RING COMPOUND | Astellas Pharma Inc. (JP) | 2009-11-18 | — | — | EP | disclosed |