Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | HEXA | P06865 | 1/20 | 0.38 |
| ▸ | HEXB | P07686 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15929451 | 0.81 | RAB9A (0.39) | ADORA2ARAB9ASMN1; SMN2NPC1CASP3 | |
| SCHEMBL13617343 | 0.78 | ALDH1A1 (0.43) | DPP4RAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL13616805 | 0.78 | MPL (0.47) | ADORA2ADPP4NPC1ALDH1A1HSD17B10 | |
| SCHEMBL13616783 | 0.76 | KDM4E (0.53) | ADORA2ARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL15928081 | 0.75 | RAB9A (0.35) | ADORA2ARAB9ASMN1; SMN2NPC1CASP3 | |
| SCHEMBL13616971 | 0.71 | MPL (0.38) | ADORA2ASMN1; SMN2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL13616808 | 0.71 | ALDH1A1 (0.46) | ADORA2APIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL6223538 | 0.71 | KDM4E (0.45) | PRKDCRAB9ANPC1ALDH1A1CYP1A2 | |
| SCHEMBL15692562 | 0.69 | KDM4E (0.50) | NOS3NOS1NOS2RAB9ASMN1; SMN2 | |
| SCHEMBL13617070 | 0.69 | GRM2 (0.37) | NOS3NOS1NOS2KDRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119716-A1 | AZA-BRIDGED-RING COMPOUND | Astellas Pharma Inc. (JP) | 2009-11-18 | — | — | EP | disclosed |