SCHEMBL13618918

SCHEMBL13618918

Cc1cc(NCCc2ccc(C(F)(F)F)cc2)ccc1O

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ESRRG P62508 1/20 0.48
RORC P51449 2/20 0.46
CNR1 P21554 1/20 0.44
FFAR1 O14842 1/20 0.44
ESR1 P03372 5/20 0.42
ESR2 Q92731 3/20 0.42
AR P10275 2/20 0.42
MCHR1 Q99705 1/20 0.41
TAAR1 Q96RJ0 1/20 0.40
TMEM97 Q5BJF2 1/20 0.39
MEN1 O00255 1/20 0.39
LMNA P02545 1/20 0.39
MAPT P10636 1/20 0.39
HTT P42858 1/20 0.39
KMT2A Q03164 1/20 0.39
PLAAT3 P53816 1/20 0.39
PLAAT5 Q96KN8 1/20 0.39
PLAAT2 Q9NWW9 1/20 0.39
PLAAT4 Q9UL19 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3644611 0.87 ALDH1A1 (0.47) RORCCNR1FFAR1MCHR1TAAR1
SCHEMBL3646051 0.84 CNR1 (0.45) RORCCNR1FFAR1MCHR1TAAR1
SCHEMBL3646704 0.83 CNR1 (0.47) RORCCNR1FFAR1MCHR1TAAR1
SCHEMBL3647799 0.80 RORC (0.48) RORCCNR1FFAR1MCHR1MEN1
SCHEMBL608498 0.80 KDM4C (0.53) RORCCNR1FFAR1MAPTPLAAT3
SCHEMBL7917864 0.80 CDK1 (0.46) RORCCNR1FFAR1MCHR1MEN1
SCHEMBL1581297 0.79 FFAR1 (0.57) RORCCNR1FFAR1TAAR1MAPT
SCHEMBL1169878 0.79 EGFR (0.52) RORCCNR1FFAR1MAPT
SCHEMBL4116154 0.79 KDM4C (0.52) RORCCNR1FFAR1MAPTPLAAT3
SCHEMBL14346892 0.79 FFAR1 (0.49) RORCCNR1FFAR1PLAAT3PLAAT5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090281181-A1 Pharmaceutical Composition for Treating or Preventing Degenerative and Inflammatory Diseases GNT PHARMA CO., LTD. (KR) 2009-11-12 US disclosed
US-20090240079-A1 Pharmaceutical Composition for Treating or Preventing Degenerative and Inflammatory Diseases NEUROTECH PHARMACEUTICALS CO., LTD. (KR) 2009-09-24 US disclosed
US-20090149542-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING NEURONAL DEATH OR NEUROLOGICAL DYSFUNCTION NEUROTECH PHARMACEUTICALS CO., LTD. (KR) 2009-06-11 US disclosed
US-20070298129-A1 Compounds and compositions for treating neuronal death or neurological dysfunction NEUROTECH PHARMACEUTICALS CO., LTD. (KR) 2007-12-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090149542-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING NEURONAL DEATH OR NEUROLOGICAL DYSFUNCTION BCL2, BAX, SMN1; SMN2 ESRRG 1349/4885RORC 3540/4885CNR1 3748/4885
US-20090240079-A1 Pharmaceutical Composition for Treating or Preventing Degenerative and Inflammatory Diseases ALOX12, ALOX15, ALOX15B ESRRG 1752/4885RORC 905/4885CNR1 4078/4885
US-20070298129-A1 Compounds and compositions for treating neuronal death or neurological dysfunction BCL2, BAX, SMN1; SMN2 ESRRG 1349/4885RORC 3540/4885CNR1 3748/4885
US-20090281181-A1 Pharmaceutical Composition for Treating or Preventing Degenerative and Inflammatory Diseases ALOX12, ALOX15, ALOX15B ESRRG 1752/4885RORC 905/4885CNR1 4078/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.