Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 5/20 | 0.41 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17103115 | 0.81 | HCAR3 (0.47) | LMNATSHRNPSR1NPC1RAB9A | |
| SCHEMBL12421884 | 0.80 | NPC1 (0.49) | LMNATSHRNPSR1NPC1RAB9A | |
| SCHEMBL12380477 | 0.79 | HCAR3 (0.46) | LMNATSHRNPSR1NPC1RAB9A | |
| SCHEMBL12421886 | 0.78 | SLC9A1 (0.38) | NPC1RAB9AHCAR3MAPTKMO | |
| SCHEMBL6184141 | 0.77 | HCAR3 (0.56) | LMNATSHRNPSR1NPC1RAB9A | |
| SCHEMBL27965846 | 0.75 | HCAR3 (0.40) | LMNATSHRNPSR1NPC1RAB9A | |
| SCHEMBL15687432 | 0.74 | MAPT (0.53) | LMNATSHRNPSR1NPC1RAB9A | |
| SCHEMBL2884485 | 0.73 | HCAR3 (0.53) | LMNATSHRNPSR1NPC1RAB9A | |
| SCHEMBL31377132 | 0.72 | LMNA (0.44) | LMNATSHRNPSR1NPC1RAB9A | |
| SCHEMBL12421885 | 0.70 | HCAR3 (0.58) | LMNATSHRNPSR1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009140553-A2 | HYPOXIA ACTIVATED DRUGS OF NITROGEN MUSTARD ALKYLATORS | THRESHOLD PHARMACEUTICALS, INC. (US) | 2009-11-19 | — | — | WO | disclosed |