Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 2/20 | 0.37 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | SI | P14410 | 2/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31132967 | 0.91 | HCAR3 (0.58) | HCAR3LMNATSHRNPSR1NPC1 | |
| SCHEMBL12421885 | 0.91 | HCAR3 (0.58) | HCAR3LMNATSHRNPSR1NPC1 | |
| SCHEMBL12421884 | 0.81 | NPC1 (0.49) | HCAR3LMNATSHRNPSR1NPC1 | |
| SCHEMBL12380478 | 0.79 | RAB9A (0.38) | HCAR3LMNANPC1RAB9AMAPT | |
| SCHEMBL13619476 | 0.79 | LMNA (0.42) | HCAR3LMNATSHRNPSR1NPC1 | |
| SCHEMBL13619477 | 0.78 | KDM4E (0.42) | LMNANPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL6184141 | 0.78 | HCAR3 (0.56) | HCAR3LMNATSHRNPSR1NPC1 | |
| SCHEMBL17103115 | 0.77 | HCAR3 (0.47) | HCAR3LMNATSHRNPSR1NPC1 | |
| SCHEMBL12709757 | 0.76 | KDM4E (0.53) | LMNATSHRNPSR1NPC1RAB9A | |
| SCHEMBL31377132 | 0.75 | LMNA (0.44) | HCAR3LMNATSHRNPSR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8309554-B2 | Hypoxia activated drugs of nitrogen mustard alkylators | THRESHOLD PHARMACEUTICALS (US) | 2012-11-13 | — | — | US | disclosed |
| US-20110190310-A1 | Hypoxia Activated Drugs Of Nitrogen Mustard Alkylators | THRESHOLD PHARMACEUTICALS, INC. | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190310-A1 | Hypoxia Activated Drugs Of Nitrogen Mustard Alkylators | HIF1AN, HIF1A, HYOU1 | HCAR3 175/4885LMNA 3450/4885TSHR 2797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.