Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.47 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3310982 | 0.80 | MAPT (0.56) | MAPTMAPK1L3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL13619902 | 0.77 | ALDH1A1 (0.43) | MAPTMAPK1L3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL13619906 | 0.77 | L3MBTL1 (0.46) | MAPTMAPK1L3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL8290211 | 0.77 | MAPT (0.54) | MAPTMAPK1L3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL13619908 | 0.77 | ALDH1A1 (0.40) | MAPTTSHRTDP1KMT2ASMN1; SMN2 | |
| SCHEMBL16727259 | 0.76 | KMT2A (0.50) | MAPTTSHRTDP1MEN1KMT2A | |
| SCHEMBL16727258 | 0.76 | MEN1 (0.41) | MAPTMAPK1L3MBTL1CYP3A4TDP1 | |
| SCHEMBL27389983 | 0.76 | CA1 (0.58) | MAPTMAPK1L3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL218018 | 0.76 | MAPT (0.78) | MAPTMAPK1L3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL21474173 | 0.76 | MAPT (0.60) | MAPTMAPK1L3MBTL1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150141378-A1 | NITROXYL PROGENITOR COMPOUNDS AND METHODS OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-05-21 | — | — | US | disclosed |
| US-20090281067-A1 | Nitroxyl progenitor compounds and methods of use | THE JOHN HOPKINS UNIVERSITY (US) | 2009-11-12 | — | — | US | disclosed |
| US-20090281067-A1 | Nitroxyl progenitor compounds and methods of use | THE JOHN HOPKINS UNIVERSITY (US) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281067-A1 | Nitroxyl progenitor compounds and methods of use | HMOX2, NNMT, HMOX1 | MAPT 3525/4885MAPK1 4047/4885L3MBTL1 889/4885 |
| US-20150141378-A1 | NITROXYL PROGENITOR COMPOUNDS AND METHODS OF USE | HMOX2, NNMT, HMOX1 | MAPT 3525/4885MAPK1 4047/4885L3MBTL1 889/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.