Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.48 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11591796 | 0.79 | ADORA1 (0.53) | KDM4EKMT2AADORA1ADORA2ASHMT2 | |
| SCHEMBL29110299 | 0.76 | ALDH1A1 (0.41) | KDM4EKMT2ASHMT2 | |
| SCHEMBL30611217 | 0.76 | ALDH1A1 (0.41) | KDM4EKMT2ASHMT2 | |
| SCHEMBL13348756 | 0.72 | KDM4E (0.43) | KDM4EKMT2ASHMT2 | |
| SCHEMBL11591322 | 0.72 | KDM4E (0.53) | KDM4EKMT2A | |
| SCHEMBL3320128 | 0.71 | KDM4E (0.64) | KDM4EKMT2AADORA1ADORA2A | |
| SCHEMBL2965562 | 0.71 | ADORA1 (0.70) | ADORA1ADORA2A | |
| SCHEMBL1227438 | 0.71 | KMT2A (0.40) | KDM4EKMT2ASHMT2 | |
| SCHEMBL30575356 | 0.70 | ALDH1A1 (0.53) | KDM4EADORA1ADORA2A | |
| SCHEMBL2294638 | 0.70 | ALDH1A1 (0.53) | KDM4EADORA1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090286767-A1 | SUBSTITUTED QUINOLIN-4-YLAMINE ANALOGUES | NEUROGEN CORPORATION (US) | 2009-11-19 | — | — | US | disclosed |
| US-7488740-B2 | Substituted quinolin-4-ylamine analogues | NEUROGEN CORPORATION (US) | 2009-02-10 | — | — | US | disclosed |
| US-20080085901-A1 | Heteroaryl Substituted Quinolin-4-Ylamine Analogues | NEUROGEN CORPORATION (US) | 2008-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286767-A1 | SUBSTITUTED QUINOLIN-4-YLAMINE ANALOGUES | PIGS, HRH4, GPR52 | KDM4E 2241/4885KMT2A 1498/4885ADORA1 220/4885 |
| US-20080085901-A1 | Heteroaryl Substituted Quinolin-4-Ylamine Analogues | PIGS, GPR52, GPR174 | KDM4E 2834/4885KMT2A 2079/4885ADORA1 191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.