Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3214990 | 0.78 | TDO2 (0.36) | ALDH1A1MAPK1L3MBTL3TDP1MAPK8 | |
| SCHEMBL19005767 | 0.67 | CHRNB4 (0.38) | L3MBTL3 | |
| SCHEMBL879232 | 0.66 | HSD11B1 (0.53) | L3MBTL3 | |
| SCHEMBL18711711 | 0.66 | HSD11B1 (0.53) | L3MBTL3 | |
| SCHEMBL18711710 | 0.66 | HSD11B1 (0.53) | L3MBTL3 | |
| SCHEMBL18478535 | 0.66 | HSD11B1 (0.53) | L3MBTL3 | |
| SCHEMBL11198170 | 0.65 | ALDH1A1 (0.36) | ALDH1A1KDM4EMAPTMITFTDP1 | |
| SCHEMBL11197082 | 0.65 | ADRA2C (0.36) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL1197270 | 0.63 | RAB9A (0.63) | ALDH1A1MAPK1MAPTHTT | |
| SCHEMBL19493962 | 0.63 | RAB9A (0.63) | ALDH1A1MAPK1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612088-B2 | Heterocyclic compounds and their use as aldosterone synthase inhibitors | SPEEDEL EXPERIMENTA AG (CH) | 2009-11-03 | — | — | US | disclosed |