Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 6/20 | 0.46 |
| ▸ | MAOA | P21397 | 3/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13624774 | 0.82 | HSD17B10 (0.53) | GAAMAOBMAOAMEN1KMT2A | |
| SCHEMBL23749844 | 0.82 | HSD17B10 (0.53) | GAAMAOBMAOAMEN1KMT2A | |
| SCHEMBL14981678 | 0.81 | GAA (0.46) | TGM2GAAMAOBMAOAALDH1A1 | |
| SCHEMBL14981720 | 0.79 | GPR35 (0.35) | MEN1KMT2ARAB9ANPC1ALOX15 | |
| SCHEMBL13624691 | 0.79 | SIGMAR1 (0.49) | GAAMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL13624994 | 0.79 | TP53 (0.52) | KMT2ARAB9ANPC1LMNAALDH1A1 | |
| SCHEMBL14981681 | 0.76 | SYK (0.41) | — | |
| SCHEMBL167814 | 0.76 | GAA (0.61) | TGM2GAAMAOBMAOAIDO1 | |
| SCHEMBL2085653 | 0.72 | TGM2 (0.66) | TGM2GAAMAOBMAOAIDO1 | |
| SCHEMBL11878139 | 0.72 | IDO1 (0.58) | TGM2GAAMAOBMAOAIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009136995-A2 | INHIBITORS OF SYK PROTEIN KINASE | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |