Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | PLAU | P00749 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13624774 | 0.82 | HSD17B10 (0.53) | RXFP1SMN1; SMN2RAB9AALDH1A1PKM | |
| SCHEMBL23749844 | 0.82 | HSD17B10 (0.53) | RXFP1SMN1; SMN2RAB9AALDH1A1PKM | |
| SCHEMBL13624876 | 0.79 | TGM2 (0.51) | TP53TSHRSMN1; SMN2LMNARAB9A | |
| SCHEMBL13624691 | 0.78 | SIGMAR1 (0.49) | SMN1; SMN2LMNARAB9ANPC1ALDH1A1 | |
| SCHEMBL30233708 | 0.78 | TP53 (0.62) | TP53TSHRRXFP1SMN1; SMN2LMNA | |
| SCHEMBL14981678 | 0.78 | GAA (0.46) | TP53TSHRSMN1; SMN2L3MBTL1PLAU | |
| SCHEMBL166106 | 0.78 | TP53 (0.66) | TP53TSHRRXFP1SMN1; SMN2LMNA | |
| SCHEMBL14981720 | 0.76 | GPR35 (0.35) | TP53TSHRSMN1; SMN2RAB9ANPC1 | |
| Bicarbonate SCHEMBL8492631 | 0.76 | NPC1 (0.61) | TP53TSHRRXFP1SMN1; SMN2LMNA | |
| Bicarbonate SCHEMBL27820322 | 0.76 | NPC1 (0.61) | TP53TSHRRXFP1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009136995-A2 | INHIBITORS OF SYK PROTEIN KINASE | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |