Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | CFTR | P13569 | 6/20 | 0.57 |
| ▸ | NAMPT | P43490 | 8/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | F10 | P00742 | 1/20 | 0.51 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.51 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.51 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626492 | 0.90 | CFTR (0.55) | LMNAPKMCFTRNAMPTMEN1 | |
| SCHEMBL13626514 | 0.88 | LMNA (0.53) | LMNAPKMCFTRNAMPTMEN1 | |
| SCHEMBL13626515 | 0.88 | LMNA (0.53) | LMNAPKMCFTRNAMPTMEN1 | |
| SCHEMBL13626503 | 0.81 | CFTR (0.56) | LMNAPKMCFTRMEN1GAA | |
| SCHEMBL3832189 | 0.81 | RHOC (0.58) | LMNA | |
| SCHEMBL8273019 | 0.81 | RHOC (0.58) | LMNA | |
| SCHEMBL3693911 | 0.80 | CFTR (0.49) | LMNAPKMCFTRMEN1GAA | |
| SCHEMBL3693915 | 0.80 | F10 (0.54) | LMNAPKMCFTRMEN1GAA | |
| SCHEMBL4558064 | 0.79 | TAS1R3 (0.60) | LMNAPKMCFTRMEN1GAA | |
| SCHEMBL13626504 | 0.79 | NAMPT (0.51) | LMNAPKMCFTRNAMPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |