Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | CFTR | P13569 | 6/20 | 0.53 |
| ▸ | F10 | P00742 | 2/20 | 0.53 |
| ▸ | NAMPT | P43490 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.47 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626502 | 0.88 | LMNA (0.58) | LMNAPKMCFTRF10NAMPT | |
| SCHEMBL13626514 | 0.84 | LMNA (0.53) | LMNAPKMCFTRF10NAMPT | |
| SCHEMBL13626492 | 0.80 | CFTR (0.55) | LMNAPKMCFTRF10NAMPT | |
| SCHEMBL13626511 | 0.79 | F10 (0.70) | CFTRF10 | |
| SCHEMBL13626503 | 0.77 | CFTR (0.56) | LMNAPKMCFTRF10MEN1 | |
| SCHEMBL4558064 | 0.76 | TAS1R3 (0.60) | LMNAPKMCFTRMEN1GAA | |
| SCHEMBL13626553 | 0.74 | F10 (0.61) | CFTRF10 | |
| SCHEMBL13626552 | 0.74 | F10 (0.61) | CFTRF10 | |
| SCHEMBL3922223 | 0.74 | CFTR (0.69) | LMNAPKMCFTR | |
| SCHEMBL13626560 | 0.73 | F10 (0.52) | LMNAPKMCFTRF10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |