Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 9/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.47 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 2/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | PROC | P04070 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626527 | 0.88 | CFTR (0.46) | CFTRLMNAPKMMAPTTAS1R3 | |
| SCHEMBL13626534 | 0.86 | CFTR (0.49) | CFTRMAPTF10 | |
| SCHEMBL13626543 | 0.86 | CFTR (0.41) | CFTRLMNAPKMF10 | |
| SCHEMBL13626501 | 0.84 | CFTR (0.59) | CFTRLMNAPKM | |
| SCHEMBL13626492 | 0.83 | CFTR (0.55) | CFTRLMNAPKMMAPTPOLB | |
| SCHEMBL13626502 | 0.81 | LMNA (0.58) | CFTRLMNAPKMTAS1R3TAS1R1 | |
| SCHEMBL13626517 | 0.81 | CFTR (0.50) | CFTRLMNAPKMMAPTPOLB | |
| SCHEMBL8282294 | 0.79 | F10 (0.55) | MAPTPOLBMEN1KMT2AF10 | |
| SCHEMBL4558064 | 0.79 | TAS1R3 (0.60) | CFTRLMNAPKMPOLBCYP3A4 | |
| SCHEMBL13626481 | 0.77 | CFTR (0.49) | CFTRLMNAPKMMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |