Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 9/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | BCL2 | P10415 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626503 | 0.81 | CFTR (0.56) | CFTRLMNAPKMPOLBCYP3A4 | |
| SCHEMBL13626481 | 0.78 | CFTR (0.49) | CFTRLMNAPKMPOLBCYP3A4 | |
| SCHEMBL13626484 | 0.78 | CFTR (0.49) | CFTRLMNAPKMPOLBCYP3A4 | |
| SCHEMBL13626490 | 0.78 | CFTR (0.49) | CFTRLMNAPKMPOLBCYP3A4 | |
| SCHEMBL4558064 | 0.77 | TAS1R3 (0.60) | CFTRLMNAPKMPOLBCYP3A4 | |
| SCHEMBL13626506 | 0.77 | NAMPT (0.50) | CFTRMEN1KMT2AGAA | |
| SCHEMBL13626552 | 0.76 | F10 (0.61) | CFTR | |
| SCHEMBL13626553 | 0.76 | F10 (0.61) | CFTR | |
| SCHEMBL13626502 | 0.76 | LMNA (0.58) | CFTRLMNAPKMTAS1R3TAS1R1 | |
| SCHEMBL13626504 | 0.75 | NAMPT (0.51) | CFTRLMNAPKMPOLBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |