Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 7/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.40 |
| ▸ | RHOA | P61586 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | UBE2M | P61081 | 1/20 | 0.38 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626492 | 0.87 | CFTR (0.55) | CFTRMEN1GAAKMT2ALMNA | |
| SCHEMBL13626527 | 0.86 | CFTR (0.46) | CFTRMEN1GAAKMT2ALMNA | |
| SCHEMBL13626533 | 0.81 | SMN1; SMN2 (0.49) | CFTRMAPTL3MBTL1ALDH1A1TSHR | |
| SCHEMBL13626502 | 0.78 | LMNA (0.58) | CFTRMEN1GAAKMT2ALMNA | |
| SCHEMBL13626522 | 0.78 | CFTR (0.40) | CFTRMEN1GAAKMT2ATAS1R3 | |
| SCHEMBL13626503 | 0.73 | CFTR (0.56) | CFTRMEN1GAAKMT2ALMNA | |
| SCHEMBL13626514 | 0.69 | LMNA (0.53) | CFTRMEN1GAAKMT2ALMNA | |
| SCHEMBL13626515 | 0.69 | LMNA (0.53) | CFTRMEN1GAAKMT2ALMNA | |
| SCHEMBL12134196 | 0.69 | F10 (0.57) | MEN1KMT2ALMNARAB9A | |
| SCHEMBL13626504 | 0.68 | NAMPT (0.51) | CFTRMEN1GAAKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |