Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 6/20 | 0.45 |
| ▸ | NAMPT | P43490 | 11/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626559 | 0.86 | MEN1 (0.51) | MEN1GAAKMT2ATAS1R3TAS1R1 | |
| SCHEMBL13626558 | 0.81 | MEN1 (0.53) | MEN1GAAKMT2ATAS1R3TAS1R1 | |
| SCHEMBL13626507 | 0.79 | KMT2A (0.52) | MEN1GAAKMT2ATAS1R3TAS1R1 | |
| SCHEMBL13626511 | 0.78 | F10 (0.70) | F10 | |
| SCHEMBL4558064 | 0.73 | TAS1R3 (0.60) | MEN1GAAKMT2ATAS1R3TAS1R1 | |
| SCHEMBL4607194 | 0.73 | F10 (0.59) | F10 | |
| SCHEMBL4606478 | 0.73 | F10 (0.59) | F10 | |
| SCHEMBL13626515 | 0.72 | LMNA (0.53) | MEN1GAAKMT2ATAS1R3TAS1R1 | |
| SCHEMBL8262976 | 0.71 | F10 (0.47) | F10 | |
| SCHEMBL85147 | 0.70 | F10 (0.66) | F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |