Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.51 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.51 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.51 |
| ▸ | NAMPT | P43490 | 10/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PREP | P48147 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626558 | 0.82 | MEN1 (0.53) | KMT2AMEN1GAATAS1R3TAS1R1 | |
| SCHEMBL76181 | 0.81 | F10 (0.47) | KCNH2NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL13626559 | 0.80 | MEN1 (0.51) | KMT2AMEN1GAATAS1R3TAS1R1 | |
| SCHEMBL13626561 | 0.79 | MEN1 (0.47) | KMT2AMEN1GAATAS1R3TAS1R1 | |
| SCHEMBL4558064 | 0.77 | TAS1R3 (0.60) | KMT2AMEN1GAATAS1R3TAS1R1 | |
| SCHEMBL13626504 | 0.73 | NAMPT (0.51) | KMT2AMEN1GAATAS1R3TAS1R1 | |
| SCHEMBL13626549 | 0.73 | NAMPT (0.51) | KMT2AMEN1GAATAS1R3TAS1R1 | |
| SCHEMBL13626550 | 0.73 | NAMPT (0.51) | KMT2AMEN1GAATAS1R3TAS1R1 | |
| SCHEMBL13626560 | 0.73 | F10 (0.52) | KMT2AMEN1GAATAS1R3TAS1R1 | |
| SCHEMBL13626502 | 0.72 | LMNA (0.58) | KMT2AMEN1GAATAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |