Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.53 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.53 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.53 |
| ▸ | NAMPT | P43490 | 14/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626559 | 0.83 | MEN1 (0.51) | MEN1GAAKMT2ATAS1R3TAS1R1 | |
| SCHEMBL13626507 | 0.82 | KMT2A (0.52) | MEN1GAAKMT2ATAS1R3TAS1R1 | |
| SCHEMBL13626561 | 0.81 | MEN1 (0.47) | MEN1GAAKMT2ATAS1R3TAS1R1 | |
| SCHEMBL13626552 | 0.77 | F10 (0.61) | F10 | |
| SCHEMBL13626553 | 0.77 | F10 (0.61) | F10 | |
| SCHEMBL4558064 | 0.76 | TAS1R3 (0.60) | MEN1GAAKMT2ATAS1R3TAS1R1 | |
| SCHEMBL701870 | 0.72 | TAS1R3 (1.00) | MEN1GAAKMT2ATAS1R3TAS1R1 | |
| SCHEMBL13626502 | 0.71 | LMNA (0.58) | MEN1GAAKMT2ATAS1R3TAS1R1 | |
| SCHEMBL4604418 | 0.71 | F10 (0.78) | F10 | |
| SCHEMBL4606847 | 0.71 | F10 (0.78) | F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |