Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.33 |
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | HTR2B | P41595 | 3/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | BPTF | Q12830 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4483043 | 1.00 | HTR2C (0.33) | HTR2CHTR2AHTR2BCHRNA4ALDH1A1 | |
| SCHEMBL4250357 | 0.83 | HTR2C (0.38) | HTR2C | |
| SCHEMBL13627312 | 0.83 | HTR2C (0.38) | HTR2C | |
| SCHEMBL13627327 | 0.80 | TRPA1 (0.42) | HTR2CHTR2AHTR2B | |
| SCHEMBL4482328 | 0.80 | TRPA1 (0.42) | HTR2CHTR2AHTR2B | |
| SCHEMBL4478989 | 0.80 | TRPA1 (0.42) | HTR2CHTR2AHTR2B | |
| SCHEMBL4469750 | 0.77 | HTR2C (0.42) | HTR2CCHRNA4MAPT | |
| SCHEMBL13627329 | 0.77 | HTR2C (0.42) | HTR2CCHRNA4MAPT | |
| SCHEMBL13627323 | 0.77 | HTR2C (0.37) | HTR2CHTR2AHTR2BALDH1A1MAPT | |
| SCHEMBL4478534 | 0.77 | HTR2C (0.37) | HTR2CHTR2AHTR2BALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618980-B2 | Pyrrolo(oxo)quinolines as 5HT ligands | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-11-17 | — | — | US | disclosed |