Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | CCR1 | P32246 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13627655 | 0.87 | PDK4 (0.42) | NPC1CCR1NAMPTKMT2ASYK | |
| SCHEMBL13627676 | 0.81 | CDK9 (0.37) | SYK | |
| SCHEMBL13627810 | 0.79 | CCR1 (0.46) | CCR1KMT2ASYKALOX15TSHR | |
| SCHEMBL13627582 | 0.78 | KCNH2 (0.50) | NPC1CCR1NAMPTKMT2AKCNH2 | |
| SCHEMBL13627581 | 0.74 | NAMPT (0.39) | NPC1CCR1NAMPTKMT2AKCNH2 | |
| SCHEMBL13628658 | 0.73 | KMT2A (0.38) | CCR1KMT2ASYKALDH1A1ALOX15 | |
| SCHEMBL2239831 | 0.71 | NAMPT (0.66) | NPC1NAMPTKMT2AKCNH2HRH3 | |
| SCHEMBL4793472 | 0.71 | CCR1 (0.47) | NPC1CCR1KMT2ACRHBPCRHR2 | |
| SCHEMBL19989639 | 0.69 | NAMPT (0.67) | NPC1NAMPTKMT2AKCNH2HRH3 | |
| SCHEMBL2246819 | 0.69 | KCNH2 (0.52) | NPC1CCR1NAMPTKMT2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618970-B2 | 3-aminocyclopentanecarboxamides as modulators of chemokine receptors | INCYTE CORPORATION (US) | 2009-11-17 | — | — | US | disclosed |