Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | SMARCA4 | P51532 | 4/20 | 0.34 |
| ▸ | PBRM1 | Q86U86 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9279188 | 0.81 | ALOX5 (0.37) | PABPC1SMARCA4PBRM1KDM4EHSD17B10 | |
| SCHEMBL9258757 | 0.77 | TNFRSF1A (0.43) | KDM4EHSD17B10HRH4MEN1KMT2A | |
| SCHEMBL5774331 | 0.74 | GRM2 (0.35) | KDM4EHSD17B10CDK5CDK5R1CYP1A1 | |
| SCHEMBL9259549 | 0.73 | HTR2A (0.44) | PABPC1KMT2AHTR2AHTR2C | |
| SCHEMBL18202213 | 0.70 | PABPC1 (0.49) | PABPC1SMARCA4PBRM1KDM4EHSD17B10 | |
| SCHEMBL946353 | 0.69 | MEN1 (0.39) | KDM4EHSD17B10MEN1KMT2ACYP1A1 | |
| SCHEMBL17323108 | 0.68 | PARP1 (0.32) | PARP1 | |
| SCHEMBL2018382 | 0.67 | ALDH1A1 (0.41) | KDM4EHSD17B10MEN1KMT2ACYP1A1 | |
| SCHEMBL13618587 | 0.67 | PABPC1 (0.49) | PABPC1KDM4EHSD17B10MEN1KMT2A | |
| SCHEMBL6977937 | 0.66 | MEN1 (0.40) | PABPC1KDM4EHSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618979-B2 | Pyridopyrrolizine and pyridoindolizine derivatives | MERCK FROSST CANADA LTD. (CA) | 2009-11-17 | — | — | US | disclosed |