Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.43 |
| ▸ | FNTA | P49354 | 1/20 | 0.41 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | S100A4 | P26447 | 1/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2018382 | 0.81 | ALDH1A1 (0.41) | MEN1KMT2AUSP2S100A4CYP1A1 | |
| SCHEMBL9279188 | 0.80 | ALOX5 (0.37) | USP2CYP1A2PRKDCALDH1A1KDM4E | |
| SCHEMBL13629383 | 0.77 | PABPC1 (0.36) | MEN1KMT2AUSP2CYP1A1CYP1B1 | |
| SCHEMBL9287303 | 0.74 | KDM4E (0.48) | MEN1KMT2AUSP2ALDH1A1KDM4E | |
| SCHEMBL24916750 | 0.72 | HTR6 (0.39) | MEN1KMT2ACYP1A2ALDH1A1MAPT | |
| SCHEMBL6983377 | 0.71 | KMT2A (0.50) | MEN1KMT2AUSP2S100A4CYP1A1 | |
| SCHEMBL6982969 | 0.70 | KMT2A (0.46) | MEN1KMT2AUSP2S100A4CYP1A1 | |
| SCHEMBL9259549 | 0.69 | HTR2A (0.44) | KMT2ADAO | |
| SCHEMBL9264795 | 0.69 | KDM4E (0.56) | MEN1KMT2AUSP2ALDH1A1KDM4E | |
| SCHEMBL9261555 | 0.69 | HTR2A (0.49) | TNFRSF1AMEN1KMT2AUSP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5428043-A | Tricyclic-cyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0441517-A2 | Tricyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1991-08-14 | — | — | EP | disclosed |