Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | GRM8 | O00222 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | UGCG | Q16739 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | FUBP1 | Q96AE4 | 1/20 | 0.34 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13629592 | 0.81 | KDM4E (0.37) | PTGS2KDM4ECYP1A2CYP2C9NTRK1 | |
| SCHEMBL16911136 | 0.80 | ALOX15 (0.40) | PTGS2PTGS1KDM4ECYP2C9ALOX15 | |
| SCHEMBL3385723 | 0.77 | PTGS2 (0.49) | PTGS2PTGS1KDM4ECYP1A2CYP2C9 | |
| SCHEMBL27606848 | 0.77 | ALDH1A1 (0.44) | KDM4ECYP1A2CYP2C9NTRK1LMNA | |
| SCHEMBL28260479 | 0.75 | KDM4E (0.47) | PTGS2PTGS1KDM4ECYP2C9ALOX15 | |
| SCHEMBL16911833 | 0.73 | UGCG (0.41) | KDM4EGAAALOX15UGCGMAPT | |
| SCHEMBL13629596 | 0.73 | TACR1 (0.46) | PTGS2PTGS1KDM4ETACR1MAPT | |
| SCHEMBL4882670 | 0.72 | KDM4E (0.42) | PTGS2PTGS1KDM4ENTRK1 | |
| SCHEMBL2051437 | 0.72 | NR3C2 (0.41) | KDM4ECYP1A2CYP2C9UGCGMAPT | |
| SCHEMBL16911329 | 0.71 | RAB9A (0.40) | KDM4EGAAALOX15LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622487-B2 | Piperidine derivative, process for producing the same, and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |
| US-7622487-B2 | Piperidine derivative, process for producing the same, and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |