Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 2/20 | 0.46 |
| ▸ | SMARCA2 | P51531 | 8/20 | 0.43 |
| ▸ | SMARCA4 | P51532 | 7/20 | 0.43 |
| ▸ | TNIK | Q9UKE5 | 3/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13632608 | 0.81 | GRM4 (0.46) | GRM4SMARCA2SMARCA4TNIKKDM4E | |
| SCHEMBL3996779 | 0.77 | FGFR2 (0.47) | MAPT | |
| SCHEMBL15542524 | 0.75 | TDP1 (0.45) | GRM4SMARCA2SMARCA4RECQLKDM4E | |
| SCHEMBL13621844 | 0.75 | EPHX2 (0.50) | GRM4SMARCA2SMARCA4SCN9A | |
| SCHEMBL3997045 | 0.74 | GRM4 (0.50) | GRM4MAPT | |
| SCHEMBL14294396 | 0.72 | APP (0.56) | TNIKMEN1MAPTKMT2A | |
| SCHEMBL14300020 | 0.72 | TXN (0.54) | GRM4TNIKKDM4EMEN1MAPT | |
| SCHEMBL1415496 | 0.72 | ALDH1A1 (0.52) | GRM4SMARCA2SMARCA4CHEK1KDM4E | |
| SCHEMBL2486834 | 0.71 | GRM4 (0.52) | GRM4TNIKKDM4EMEN1NPC1 | |
| SCHEMBL3946380 | 0.69 | HTR3E (0.55) | GRM4MEN1NPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622486-B2 | Pyridine compounds, process for their preparation and compositions containing them | REDDY US THERAPEUTICS, INC. (US) | 2009-11-24 | — | — | US | disclosed |