Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.45 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11600370 | 0.80 | ALDH1A1 (0.56) | POLBSMN1; SMN2TSHRL3MBTL1ALDH1A1 | |
| SCHEMBL29490252 | 0.79 | POLB (0.54) | POLBSMN1; SMN2TSHRL3MBTL1ALDH1A1 | |
| SCHEMBL22862558 | 0.79 | POLB (0.54) | POLBSMN1; SMN2TSHRL3MBTL1ALDH1A1 | |
| SCHEMBL12136691 | 0.79 | RAB9A (0.57) | POLBSMN1; SMN2TSHRL3MBTL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11603001 | 0.79 | ALDH1A1 (0.55) | POLBSMN1; SMN2TSHRL3MBTL1ALDH1A1 | |
| SCHEMBL13156353 | 0.78 | POLB (0.53) | POLBSMN1; SMN2TSHRL3MBTL1ALDH1A1 | |
| SCHEMBL9388512 | 0.78 | POLB (0.53) | POLBSMN1; SMN2TSHRL3MBTL1ALDH1A1 | |
| SCHEMBL22862551 | 0.78 | POLB (0.53) | POLBSMN1; SMN2TSHRL3MBTL1ALDH1A1 | |
| SCHEMBL29490174 | 0.78 | POLB (0.53) | POLBSMN1; SMN2TSHRL3MBTL1ALDH1A1 | |
| SCHEMBL7479892 | 0.78 | POLB (0.53) | POLBSMN1; SMN2TSHRL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615651-B2 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER INC. (US) | 2009-11-10 | — | — | US | disclosed |
| US-7615651-B2 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER INC. (US) | 2009-11-10 | — | — | US | disclosed |
| US-20080167371-A1 | Diaryl, Dipyridinyl and Aryl-Pyridinyl Derivatives and Uses Thereof | PFIZER INC. | 2008-07-10 | — | — | US | disclosed |
| US-20080167371-A1 | Diaryl, Dipyridinyl and Aryl-Pyridinyl Derivatives and Uses Thereof | PFIZER INC. | 2008-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167371-A1 | Diaryl, Dipyridinyl and Aryl-Pyridinyl Derivatives and Uses Thereof | OPRD1, OPRK1, OPRL1 | POLB 782/4885SMN1; SMN2 2395/4885TSHR 367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.