Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.51 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.49 |
| ▸ | CKS1B | P61024 | 1/20 | 0.49 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16897001 | 0.85 | HSD11B1 (0.60) | KDM4ELMNAHSD11B1SMN1; SMN2POLB | |
| SCHEMBL19401395 | 0.85 | MAPT (0.56) | KDM4EALDH1A1LMNAHSD11B1SMN1; SMN2 | |
| SCHEMBL21275485 | 0.80 | KDM4E (0.59) | KDM4EALDH1A1LMNAHSD11B1SCN9A | |
| SCHEMBL13633501 | 0.79 | KDM4E (0.58) | KDM4EALDH1A1LMNASMN1; SMN2POLB | |
| SCHEMBL4636523 | 0.79 | SLC22A12 (0.44) | KDM4EALDH1A1HSD11B1SCN9ASLC22A12 | |
| SCHEMBL7587888 | 0.77 | KEAP1 (0.54) | ALDH1A1LMNAHSD11B1SMN1; SMN2POLB | |
| SCHEMBL13638237 | 0.76 | ALKBH2 (0.64) | KDM4EALDH1A1LMNASMN1; SMN2POLB | |
| SCHEMBL6554639 | 0.74 | KEAP1 (0.51) | ALDH1A1LMNAHSD11B1POLBCKS1B | |
| SCHEMBL6555449 | 0.74 | KDM1A (0.68) | ALDH1A1LMNAKMT2A | |
| SCHEMBL15215659 | 0.74 | POLB (0.72) | KDM4EALDH1A1LMNAHSD11B1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275577-A1 | IMIDAZOPYRIDINE AND IMIDAZOPYRIMIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS | PFIZER INC | 2009-11-05 | — | — | US | disclosed |
| US-20090275577-A1 | IMIDAZOPYRIDINE AND IMIDAZOPYRIMIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS | PFIZER INC | 2009-11-05 | — | — | US | disclosed |
| EP-1737459-B1 | IMIDAZOPYRIDINE AND IMIDAZOPYRIMIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS | WARNER LAMBERT CO (US) | 2009-08-05 | — | — | EP | disclosed |
| US-7563788-B2 | Substituted Imidazo[1,2-a]pyridines as Antibacterial Agents | PFIZER INC. (US) | 2009-07-21 | — | — | US | disclosed |
| US-7563788-B2 | Substituted Imidazo[1,2-a]pyridines as Antibacterial Agents | PFIZER INC. (US) | 2009-07-21 | — | — | US | disclosed |
| US-20070191394-A1 | Antibacterial agents | WARNER-LAMBERT COMPANY LLC | 2007-08-16 | — | — | US | disclosed |
| US-20070191394-A1 | Antibacterial agents | WARNER-LAMBERT COMPANY LLC | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191394-A1 | Antibacterial agents | MRPL21, RPN2, FBL | KDM4E 4500/4885ALDH1A1 637/4885LMNA 2919/4885 |
| US-20090275577-A1 | IMIDAZOPYRIDINE AND IMIDAZOPYRIMIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS | DPYD, TYMP, ITPA | KDM4E 4078/4885ALDH1A1 272/4885LMNA 3979/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.