Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.54 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6554639 | 0.88 | KEAP1 (0.51) | KEAP1NFE2L2ALDH1A1HSD11B1LMNA | |
| SCHEMBL6831807 | 0.87 | MAPT (0.54) | KEAP1NFE2L2ALDH1A1HSD11B1LMNA | |
| SCHEMBL10238213 | 0.86 | KEAP1 (0.49) | KEAP1NFE2L2ALDH1A1HSD11B1LMNA | |
| SCHEMBL7589336 | 0.84 | SLC22A12 (0.54) | ACLY | |
| SCHEMBL7590378 | 0.84 | CCR2 (0.48) | HSD11B1MAPTGAAACLYSMN1; SMN2 | |
| SCHEMBL23200283 | 0.84 | METAP2 (0.67) | LMNAPOLBCYP2C9CYP2C19L3MBTL1 | |
| SCHEMBL6553589 | 0.84 | MAPT (0.60) | KEAP1NFE2L2ALDH1A1HSD11B1LMNA | |
| SCHEMBL617823 | 0.84 | SLC22A12 (0.51) | KEAP1NFE2L2ALDH1A1HSD11B1KMT2A | |
| SCHEMBL6554533 | 0.84 | MAPT (0.60) | KEAP1NFE2L2ALDH1A1HSD11B1LMNA | |
| SCHEMBL22654320 | 0.83 | ALDH1A1 (0.54) | KEAP1NFE2L2ALDH1A1LMNAUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9856230-B2 | Enzyme inhibitors | UNIVERSITY OF SUNDERLAND (GB) | 2018-01-02 | — | — | US | disclosed |
| US-20150322035-A1 | Enzyme Inhibitors | UNIVERSITY OF SUNDERLAND (GB) | 2015-11-12 | — | — | US | disclosed |
| WO-2014096864-A9 | ENZYME INHIBITORS | UNIVERSITY OF SUNDERLAND (GB) | 2015-03-05 | — | — | WO | disclosed |
| WO-2014096864-A1 | ENZYME INHIBITORS | UNIVERSITY OF SUNDERLAND (GB) | 2014-06-26 | — | — | WO | disclosed |
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150322035-A1 | Enzyme Inhibitors | TXNRD3, TXNRD2, TXNRD1 | KEAP1 142/4885NFE2L2 108/4885ALDH1A1 687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.