Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 3/20 | 0.42 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.39 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.39 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.39 |
| ▸ | MPO | P05164 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1322809 | 0.88 | HRH3 (0.42) | ADRA1DHTR1ADRD2SLC6A4MPO | |
| SCHEMBL1323754 | 0.85 | GRIN2B (0.46) | ADRA1DHTR1ADRD2SLC6A4MPO | |
| SCHEMBL1322798 | 0.82 | GRIN2B (0.56) | HTR2ACCR3GRIN2B | |
| SCHEMBL1322882 | 0.81 | HTR1A (0.45) | HTR1ASLC6A4MPOKCNH2HTR2A | |
| SCHEMBL1322881 | 0.78 | ADRA1D (0.62) | ADRA1DHTR1ADRD2SLC6A4KCNH2 | |
| SCHEMBL1322810 | 0.78 | GRIN2B (0.48) | HTR1ADRD2SLC6A4MPOKCNH2 | |
| SCHEMBL1322807 | 0.77 | OPRK1 (0.41) | ADRA1DKCNH2ADRA1B | |
| SCHEMBL1322865 | 0.75 | SLC6A4 (0.54) | ADRA1DHTR1ADRD2SLC6A4KCNH2 | |
| SCHEMBL1324283 | 0.75 | GRIN2B (0.58) | HTR1AMPOHTR2ACCR3GRIN2B | |
| SCHEMBL16595882 | 0.71 | SLC6A4 (0.51) | HTR1ADRD2SLC6A4KCNH2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090291963-A1 | SUBSTITUTED INDOLES | SCHADT OLIVER | 2009-11-26 | — | — | US | disclosed |
| US-20090291963-A1 | SUBSTITUTED INDOLES | SCHADT OLIVER | 2009-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291963-A1 | SUBSTITUTED INDOLES | TPH2, TPH1, HTR1A | ADRA1D 29/4885HTR1A 3/4885DRD2 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.