Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 5/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4763334 | 0.91 | CYP3A4 (0.40) | MEN1KMT2AALDH1A1CYP3A4RAB9A | |
| SCHEMBL8293709 | 0.74 | PTGS2 (0.46) | LMNAMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL8906719 | 0.74 | LMNA (0.37) | LMNAMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL7679028 | 0.72 | PTGS2 (0.44) | LMNAMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL5367001 | 0.72 | MAPT (0.45) | LMNAMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL11808855 | 0.72 | ALDH1A1 (0.41) | LMNAMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL8905800 | 0.71 | AKR1B1 (0.54) | LMNAMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL5375899 | 0.71 | LMNA (0.36) | LMNAMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL8906007 | 0.70 | CXCL8 (0.37) | LMNAMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL8906334 | 0.70 | PTGS2 (0.39) | LMNAMEN1KMT2AALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090281073-A1 | HETEROAROMATIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | BHATTACHARYA SAMIT KUMAR | 2009-11-12 | — | — | US | disclosed |
| US-20090215742-A1 | AMIDE RESORCINOL COMPOUNDS | PFIZER, INC. | 2009-08-27 | — | — | US | disclosed |
| US-7537762-B2 | Human monoclonal antibodies to activin receptor-like kinase-1 | AMGEN FREMONT, INC. (US) | 2009-05-26 | — | — | US | disclosed |
| US-20090111805-A1 | BICYCLIC HETEROAROMATIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER INC. | 2009-04-30 | — | — | US | disclosed |
| US-20070065444-A1 | Human monoclonal antibodies to activin receptor-like kinase-1 | AMGEN FREMONT INC. (US) | 2007-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090111805-A1 | BICYCLIC HETEROAROMATIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | CCNB1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CCNY | LMNA 1304/4885MEN1 1512/4885KMT2A 2151/4885 |
| US-20090215742-A1 | AMIDE RESORCINOL COMPOUNDS | HSP90AB1, HSP90AA1, HSP90AB2P | LMNA 4013/4885MEN1 4482/4885KMT2A 3148/4885 |
| US-20070065444-A1 | Human monoclonal antibodies to activin receptor-like kinase-1 | SMAD3, SMAD2, ACVR1 | LMNA 1734/4885MEN1 2610/4885KMT2A 1920/4885 |
| US-20090281073-A1 | HETEROAROMATIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | CCNY, TP53, CCNE1 | LMNA 1837/4885MEN1 1005/4885KMT2A 1798/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.