Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GPR6 | P46095 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
| ▸ | RBP4 | P02753 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | GLS | O94925 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2769952 | 0.86 | ALDH1A1 (0.39) | HRH3KCNH2GAACYP2C19ALDH1A1 | |
| SCHEMBL13634244 | 0.81 | HRH3 (0.42) | HRH3KCNH2GAACYP2C19ALDH1A1 | |
| SCHEMBL13162330 | 0.78 | HRH3 (0.42) | HRH3KCNH2GAACYP2C19ALDH1A1 | |
| SCHEMBL13163111 | 0.78 | EPHX2 (0.47) | HRH3GPR6RBP4TTR | |
| SCHEMBL13634228 | 0.77 | EPHX2 (0.45) | — | |
| SCHEMBL13634227 | 0.76 | DPP4 (0.44) | KCNH2GPR6 | |
| SCHEMBL13163108 | 0.75 | EPHX2 (0.42) | KCNH2CYP2C19GPR6RBP4TTR | |
| SCHEMBL3436269 | 0.75 | HCRTR1 (0.35) | ALDH1A1NPSR1RBP4TTRGSK3B | |
| SCHEMBL13634347 | 0.72 | KDM5A (0.44) | HRH3TTR | |
| SCHEMBL3436255 | 0.72 | IRAK4 (0.41) | CYP2C19NPSR1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2206707-B1 | AZOLECARBOXAMIDE COMPOUND OR SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2014-07-23 | — | — | EP | disclosed |
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |