Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 3/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.38 |
| ▸ | MTOR | P42345 | 9/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.34 |
| ▸ | ATR | Q13535 | 2/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13163110 | 0.87 | PDK1 (0.39) | HTR3AIRAK4MTORHCRTR1HCRTR2 | |
| SCHEMBL13638968 | 0.83 | IRAK4 (0.50) | HTR3AIRAK4MTORPIK3CA | |
| SCHEMBL13634320 | 0.80 | HTR3A (0.40) | HTR3AMTORPIK3CAAURKAPDPK1 | |
| SCHEMBL15888553 | 0.76 | HCRTR1 (0.42) | IRAK4MTORPIK3CAHCRTR1HCRTR2 | |
| SCHEMBL22773890 | 0.76 | KMO (0.40) | HTR3AMTORPIK3CAAURKAPDPK1 | |
| SCHEMBL22773888 | 0.76 | KMO (0.40) | HTR3AMTORPIK3CAAURKAPDPK1 | |
| SCHEMBL1004971 | 0.72 | HTR3A (0.66) | HTR3AMTORPIK3CAATR | |
| SCHEMBL1006017 | 0.72 | HTR3A (0.66) | HTR3AMTORPIK3CAATR | |
| SCHEMBL1004970 | 0.72 | HTR3A (0.66) | HTR3AMTORPIK3CAATR | |
| SCHEMBL2079853 | 0.72 | KMO (0.49) | IRAK4PIK3CAPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |