Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 14/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | DHFR | P00374 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4378537 | 0.84 | HSD11B1 (1.00) | HSD11B1 | |
| SCHEMBL3926479 | 0.76 | HSD11B1 (0.61) | HSD11B1LMNATSHRMAPT | |
| SCHEMBL10031608 | 0.75 | ALDH1A1 (0.74) | HSD11B1SMN1; SMN2LMNACYP2C9MAPT | |
| SCHEMBL13635045 | 0.74 | HSD11B1 (1.00) | HSD11B1 | |
| SCHEMBL3926842 | 0.73 | HSD11B1 (0.62) | HSD11B1 | |
| SCHEMBL19911645 | 0.71 | HTR6 (0.70) | SMN1; SMN2LMNACYP2C9MAPTPDE4A | |
| SCHEMBL16311219 | 0.70 | PKM (0.57) | HSD11B1LMNATSHRMAPT | |
| SCHEMBL3928523 | 0.70 | HSD11B1 (0.61) | HSD11B1LMNATSHR | |
| SCHEMBL11882075 | 0.69 | L3MBTL1 (0.77) | SMN1; SMN2LMNAAURKADHFRTSHR | |
| SCHEMBL5797726 | 0.69 | HSD11B1 (0.55) | HSD11B1LMNATSHRCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893609-B1 | N-(PYRIDIN-2-YL)-SULFONAMIDE DERIVATIVES | PFIZER (US) | 2009-11-18 | — | — | EP | disclosed |