Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.50 |
| ▸ | NOS2 | P35228 | 1/20 | 0.50 |
| ▸ | FEN1 | P39748 | 3/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28811304 | 0.86 | NOS3 (0.53) | NOS3NOS1NOS2FEN1ALOX5AP | |
| SCHEMBL14684302 | 0.82 | MAOB (0.60) | NOS3NOS1NOS2KMT2AMAPT | |
| SCHEMBL24155504 | 0.81 | DYRK1A (0.43) | FEN1ALOX5APMAP4K4KMT2AMAPT | |
| SCHEMBL30046762 | 0.80 | NOS3 (0.55) | NOS3NOS1NOS2FEN1ALOX5AP | |
| SCHEMBL29854857 | 0.80 | NOS3 (0.47) | NOS3NOS1NOS2FEN1ALOX5AP | |
| SCHEMBL28811368 | 0.80 | NOS3 (0.47) | NOS3NOS1NOS2FEN1ALOX5AP | |
| SCHEMBL190964 | 0.79 | GCK (0.51) | NOS3NOS1NOS2FEN1ALOX5AP | |
| SCHEMBL19139269 | 0.79 | MRGPRX1 (0.45) | MAP4K4MAPTALDH1A1MRGPRX1 | |
| SCHEMBL7938427 | 0.79 | MAPT (0.46) | MAP4K4KMT2AMAPTMEN1MITF | |
| SCHEMBL11959791 | 0.78 | LMNA (0.47) | MAP4K4KMT2AMAPTMEN1MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119706-A1 | PYRIDINE OR PYRIMIDINE DERIVATIVE HAVING EXCELLENT CELL GROWTH INHIBITION EFFECT AND EXCELLENT ANTI-TUMOR EFFECT ON CELL STRAIN HAVING AMPLIFICATION OF HGFR GENE | Eisai R&D Management Co., Ltd. (JP) | 2009-11-18 | — | — | EP | disclosed |