Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 5/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | ITK | Q08881 | 1/20 | 0.35 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.32 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2867192 | 0.82 | TNIK (0.41) | MAPK10TNIKSIRT2SIRT1ITK | |
| SCHEMBL2867309 | 0.82 | TNIK (0.44) | MAPK10TNIKSIRT2SIRT1ITK | |
| SCHEMBL2865310 | 0.82 | TNIK (0.40) | MAPK10TNIKSIRT2SIRT1ITK | |
| SCHEMBL4335786 | 0.81 | MAPK10 (0.52) | MAPK10TNIKSIRT2SIRT1ITK | |
| SCHEMBL2871502 | 0.80 | SMN1; SMN2 (0.46) | MAPK10NTRK1NTRK3MAPTALDH1A1 | |
| SCHEMBL4345589 | 0.77 | MAPK10 (0.44) | MAPK10TNIKSIRT2SIRT1PIP5K1C | |
| SCHEMBL4340656 | 0.77 | MAPK10 (0.44) | MAPK10TNIKSIRT2SIRT1PIP5K1C | |
| SCHEMBL4337647 | 0.77 | STK33 (0.44) | MAPK10TNIKMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4342242 | 0.76 | HSD17B10 (0.43) | MAPK10TNIKITKMAPTALDH1A1 | |
| SCHEMBL2862889 | 0.75 | TNIK (0.48) | MAPK10TNIKJAK2JAK3MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1380576-B1 | 1H-INDAZOLE COMPOUNDS INHIBITING JNK | EISAI R&D MAN CO LTD (JP) | 2009-11-25 | — | — | EP | disclosed |