Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | PGK1 | P00558 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | TNFRSF1A | P19438 | 4/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4336833 | 0.82 | MAPK10 (0.40) | MAPK10PGK1MAPKAPK2SIRT2SIRT1 | |
| SCHEMBL2862326 | 0.81 | KDM4E (0.46) | MAPK10PGK1MAPKAPK2SIRT2SIRT1 | |
| SCHEMBL4329239 | 0.79 | MAPK1 (0.45) | MAPK10 | |
| SCHEMBL2864411 | 0.76 | MAPK10 (0.46) | MAPK10PGK1MAPKAPK2SIRT2SIRT1 | |
| SCHEMBL2870547 | 0.75 | RAB9A (0.48) | MAPK10MAPKAPK2SIRT2SIRT1ABL1 | |
| SCHEMBL4335941 | 0.73 | MAPT (0.49) | MAPK10MEN1KMT2A | |
| SCHEMBL4340978 | 0.73 | ALDH1A1 (0.46) | MEN1KMT2A | |
| SCHEMBL4326727 | 0.72 | TRPV3 (0.47) | MAPK10MAPKAPK2SIRT2SIRT1JAK2 | |
| SCHEMBL13198310 | 0.72 | MAPK10 (0.47) | MAPK10PGK1MAPKAPK2SIRT2SIRT1 | |
| SCHEMBL4337567 | 0.72 | MAPK10 (0.47) | MAPK10PGK1MAPKAPK2SIRT2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1380576-B1 | 1H-INDAZOLE COMPOUNDS INHIBITING JNK | EISAI R&D MAN CO LTD (JP) | 2009-11-25 | — | — | EP | disclosed |