Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 6/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4378283 | 0.78 | ALDH1A1 (0.52) | MAPTALDH1A1RXFP1GRM5TP53 | |
| SCHEMBL4377596 | 0.72 | USP2 (0.51) | MAPTALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL4378505 | 0.72 | NPC1 (0.57) | MAPTALDH1A1MC4RRXFP1LMNA | |
| SCHEMBL4378548 | 0.72 | USP2 (0.52) | MAPTALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL2829573 | 0.70 | L3MBTL1 (0.48) | MAPTALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL7090622 | 0.70 | GAA (0.55) | MAPT | |
| SCHEMBL24564645 | 0.68 | MEN1 (0.50) | MAPTALDH1A1LMNAKMT2A | |
| SCHEMBL29697017 | 0.68 | MEN1 (0.50) | MAPTALDH1A1LMNAKMT2A | |
| SCHEMBL24581213 | 0.68 | ALDH1A1 (0.42) | MAPTALDH1A1RXFP1GRM5TP53 | |
| SCHEMBL7819980 | 0.66 | KDM4E (0.42) | MAPTALDH1A1RXFP1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | disclosed |