Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12070943 | 0.80 | GPR35 (0.40) | GPR35MEN1KMT2AMAPTKDM4E | |
| SCHEMBL561626 | 0.80 | GPR35 (0.47) | GPR35MEN1KMT2AMAPTKDM4E | |
| SCHEMBL14392924 | 0.76 | GPR35 (0.44) | GPR35MEN1KMT2AMAPTKDM4E | |
| SCHEMBL6875131 | 0.74 | MAPT (0.40) | GPR35MEN1KMT2AMAPTKDM4E | |
| SCHEMBL2624139 | 0.73 | GPR35 (0.36) | GPR35MEN1KMT2AMAPTKDM4E | |
| SCHEMBL3627208 | 0.71 | TDO2 (0.51) | MEN1KMT2AMAPTKDM4EMAPK1 | |
| SCHEMBL1952047 | 0.71 | USP2 (0.39) | GPR35MEN1KMT2AMAPTKDM4E | |
| SCHEMBL998408 | 0.70 | ALDH1A1 (0.41) | MEN1KMT2AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL996497 | 0.69 | CCR1 (0.42) | MEN1KMT2AMAPTNPC1CYP1A2 | |
| SCHEMBL6877381 | 0.69 | PDGFRB (0.36) | GPR35ESR1ESR2PDE4DHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009142842-A2 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2009-11-26 | — | — | WO | disclosed |