Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | METAP1 | P53582 | 4/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30702212 | 0.80 | MAPT (0.56) | KDM4EMAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL3948845 | 0.80 | MAPT (0.56) | KDM4EMAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL856747 | 0.79 | ACHE (0.56) | KDM4EMAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL5311960 | 0.79 | KMT2A (0.55) | KDM4EMAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL23618751 | 0.77 | MAPT (0.70) | KDM4EMAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL1000380 | 0.75 | ACHE (0.51) | KDM4EMAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL19836626 | 0.75 | ALDH1A1 (0.54) | KDM4EMAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL6116289 | 0.75 | METAP1 (0.55) | KDM4EMAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL29476747 | 0.75 | ACHE (0.51) | KDM4EMAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL28699476 | 0.75 | KDM4E (0.51) | KDM4EMAPTMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622471-B2 | Pyrazole derivatives having a pyridazine and pyridine functionality | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2009-11-24 | — | — | US | disclosed |