Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | ALDH1A3 | P47895 | 3/20 | 0.46 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.45 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30679643 | 0.89 | ALDH1A1 (0.50) | ALDH1A1ALDH1A3VCAM1PTPN11ALDH3A1 | |
| SCHEMBL30185446 | 0.87 | ALDH1A1 (0.55) | ALDH1A1ALDH1A3TRIM24TRIM33VCAM1 | |
| SCHEMBL4035480 | 0.87 | ALDH1A1 (0.55) | ALDH1A1ALDH1A3TRIM24TRIM33VCAM1 | |
| SCHEMBL30185447 | 0.87 | ALDH1A1 (0.55) | ALDH1A1ALDH1A3TRIM24TRIM33VCAM1 | |
| SCHEMBL25613984 | 0.86 | ALDH1A1 (0.55) | ALDH1A1ALDH1A3TRIM24TRIM33VCAM1 | |
| SCHEMBL12577714 | 0.86 | ESR1 (0.51) | ALDH1A1TRIM24TRIM33CA12CA1 | |
| SCHEMBL4036224 | 0.85 | CYP2A6 (0.52) | ALDH1A1TRIM24TRIM33CA12CA1 | |
| SCHEMBL25382919 | 0.82 | TYR (0.47) | ALDH1A1ALDH1A3CA1CA2CA9 | |
| SCHEMBL4080102 | 0.82 | ALDH1A1 (0.43) | ALDH1A1ALDH1A3BRD4KMT2AMEN1 | |
| SCHEMBL30679637 | 0.82 | RORB (0.49) | ALDH1A1ALDH1A3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615651-B2 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER INC. (US) | 2009-11-10 | — | — | US | disclosed |
| US-20080167371-A1 | Diaryl, Dipyridinyl and Aryl-Pyridinyl Derivatives and Uses Thereof | PFIZER INC. | 2008-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167371-A1 | Diaryl, Dipyridinyl and Aryl-Pyridinyl Derivatives and Uses Thereof | OPRD1, OPRK1, OPRL1 | ALDH1A1 1390/4885ALDH1A3 2454/4885TRIM24 1176/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.