Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.35 |
| ▸ | WEE1 | P30291 | 3/20 | 0.34 |
| ▸ | DRD4 | P21917 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13638876 | 0.82 | DRD4 (0.49) | DRD4GRM2 | |
| SCHEMBL26783813 | 0.71 | CHEK1 (0.37) | SYKLRRK2ALDH1A1PIK3CDPIK3CA | |
| SCHEMBL20448415 | 0.70 | PDK1 (0.43) | SYKLRRK2PDK1FFAR2DRD4 | |
| SCHEMBL13638828 | 0.70 | ALDH1A1 (0.42) | SYKLRRK2ALDH1A1PDK1FFAR2 | |
| SCHEMBL23104507 | 0.69 | LRRK2 (0.43) | SYKLRRK2PDK1FFAR2WEE1 | |
| SCHEMBL23104773 | 0.69 | LRRK2 (0.43) | SYKLRRK2PDK1FFAR2WEE1 | |
| SCHEMBL24156928 | 0.69 | LRRK2 (0.43) | SYKLRRK2PDK1FFAR2WEE1 | |
| SCHEMBL23103879 | 0.69 | POLB (0.58) | SYKLRRK2PDK1FFAR2WEE1 | |
| SCHEMBL23089339 | 0.69 | FFAR2 (0.44) | SYKLRRK2PDK1PIK3CAFFAR2 | |
| SCHEMBL23114510 | 0.68 | LRRK2 (0.42) | SYKLRRK2PDK1FFAR2WEE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |