Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A1 | P04798 | 8/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 8/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | JUN | P05412 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14733962 | 0.80 | STING1 (0.37) | CYP1A1CYP1B1CYP1A2NFE2L2ALDH1A1 | |
| SCHEMBL12801867 | 0.80 | ALDH1A1 (0.55) | CYP1A1CYP1B1CYP1A2NFE2L2ALDH1A1 | |
| SCHEMBL12369333 | 0.79 | MAPT (0.34) | CYP1A2ALDH1A1 | |
| SCHEMBL26185782 | 0.78 | TRPA1 (0.58) | CYP1A1CYP1B1CYP1A2NFE2L2CYP19A1 | |
| SCHEMBL1792533 | 0.78 | CYP1A1 (0.61) | CYP1A1CYP1B1CYP1A2NFE2L2CYP19A1 | |
| SCHEMBL4211349 | 0.78 | ACHE (0.56) | CYP1A1CYP1B1CYP1A2NFE2L2ALDH1A1 | |
| SCHEMBL129594 | 0.76 | AMY1A (0.51) | CYP1A2ALDH1A1MEN1CYP3A4KMT2A | |
| SCHEMBL16957006 | 0.76 | KDM4E (0.48) | ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL2669476 | 0.76 | NFE2L2 (0.47) | CYP1A1CYP1B1CYP1A2NFE2L2CYP19A1 | |
| SCHEMBL14609038 | 0.76 | CYP19A1 (0.47) | CYP19A1ALDH1A1TRPA1PPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304385-B2 | Macrocyclic tetrazolyl hepatitis C serine protease inhibitors | ENANTA PHARMACEUTICALS, INC. (US) | 2012-11-06 | — | — | US | disclosed |
| US-20090142299-A1 | MACROCYCLIC TETRAZOLYL HEPATITIS C SERINE PROTEASE INHIBITORS | ENANTA PHARMACEUTICALS, INC. | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090142299-A1 | MACROCYCLIC TETRAZOLYL HEPATITIS C SERINE PROTEASE INHIBITORS | TMPRSS4, PRSS1, SPINT2 | CYP1A1 459/4885CYP1B1 633/4885CYP1A2 340/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.