Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
| ▸ | IL6 | P05231 | 6/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.30 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13639311 | 0.88 | IL6 (0.46) | MEN1KMT2ANPC1CASP3SENP8 | |
| SCHEMBL13890394 | 0.86 | KMT2A (0.33) | MEN1KMT2ANPC1CASP3SENP8 | |
| SCHEMBL4581943 | 0.83 | IL6 (0.33) | MEN1KMT2ANPC1CASP3SENP8 | |
| SCHEMBL4139580 | 0.82 | ALDH1A1 (0.40) | MEN1KMT2ANPC1CASP3SENP8 | |
| SCHEMBL4581059 | 0.82 | LMNA (0.36) | MEN1KMT2ANPC1CASP3SENP8 | |
| SCHEMBL4135760 | 0.81 | KMT2A (0.37) | MEN1KMT2ANPC1CASP3SENP8 | |
| SCHEMBL14015809 | 0.81 | IL6 (0.46) | MEN1KMT2ANPC1CASP3SENP8 | |
| SCHEMBL12658235 | 0.80 | NR3C1 (0.39) | MEN1KMT2AMAPT | |
| SCHEMBL4581463 | 0.79 | IL6 (0.39) | MEN1KMT2ANPC1CASP3SENP8 | |
| SCHEMBL12534159 | 0.79 | IL6 (0.36) | IL6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1995242-B1 | NOVEL 1,2,3,4-TETRAHYDROQUINOXALINE DERIVATIVE HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY | SANTEN PHARMACEUTICAL CO LTD (JP) | 2012-11-07 | — | — | EP | disclosed |
| EP-1995242-A1 | NOVEL 1,2,3,4-TETRAHYDROQUINOXALINE DERIVATIVE HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY | Santen Pharmaceutical Co., Ltd (JP) | 2008-11-26 | — | — | EP | disclosed |