Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL6 | P05231 | 8/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 6/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 6/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13639370 | 0.92 | IL6 (0.38) | IL6KDM4ESMN1; SMN2KMT2AMEN1 | |
| SCHEMBL14878781 | 0.88 | IL6 (0.48) | IL6KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL13639363 | 0.86 | KMT2A (0.38) | IL6KDM4EKMT2AMEN1POLB | |
| SCHEMBL12533030 | 0.84 | IL6 (0.52) | IL6 | |
| SCHEMBL12533029 | 0.83 | IL6 (0.50) | IL6 | |
| SCHEMBL13639336 | 0.81 | HCRTR1 (0.37) | IL6KDM4ELMNAHTTKMT2A | |
| SCHEMBL12533083 | 0.81 | IL6 (0.43) | IL6LMNAALDH1A1 | |
| SCHEMBL14015609 | 0.81 | DRD2 (0.36) | IL6KDM4ELMNAHTTKMT2A | |
| SCHEMBL14015835 | 0.81 | IL6 (0.39) | IL6KDM4ELMNASMN1; SMN2POLB | |
| SCHEMBL13639313 | 0.80 | IL6 (0.47) | IL6KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1995242-B1 | NOVEL 1,2,3,4-TETRAHYDROQUINOXALINE DERIVATIVE HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY | SANTEN PHARMACEUTICAL CO LTD (JP) | 2012-11-07 | — | — | EP | disclosed |