Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | IL6 | P05231 | 5/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 3/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14015609 | 0.91 | DRD2 (0.36) | IL6L3MBTL1HTR1AALDH1A1KDM4E | |
| SCHEMBL13639363 | 0.91 | KMT2A (0.38) | IL6HTR1AALDH1A1KDM4EMAPT | |
| SCHEMBL13639362 | 0.91 | HTR1A (0.37) | IL6L3MBTL1HTR1AALDH1A1KDM4E | |
| SCHEMBL13639358 | 0.91 | KMT2A (0.37) | IL6L3MBTL1HTR1AALDH1A1KDM4E | |
| SCHEMBL14015835 | 0.90 | IL6 (0.39) | IL6L3MBTL1HTR1AALDH1A1KDM4E | |
| SCHEMBL14878774 | 0.90 | ALOX15 (0.41) | IL6L3MBTL1HTR1AALDH1A1KDM4E | |
| SCHEMBL14015597 | 0.89 | MAPT (0.48) | L3MBTL1PDGFRBPDGFRAALDH1A1KDM4E | |
| SCHEMBL13639370 | 0.89 | IL6 (0.38) | IL6HTR1AALDH1A1KDM4EMAPT | |
| SCHEMBL14015605 | 0.88 | KMT2A (0.36) | IL6L3MBTL1HTR1AALDH1A1KDM4E | |
| SCHEMBL14015535 | 0.88 | ADRA1D (0.36) | IL6HTR1AALDH1A1KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1995242-B1 | NOVEL 1,2,3,4-TETRAHYDROQUINOXALINE DERIVATIVE HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY | SANTEN PHARMACEUTICAL CO LTD (JP) | 2012-11-07 | — | — | EP | disclosed |
| EP-1995242-A1 | NOVEL 1,2,3,4-TETRAHYDROQUINOXALINE DERIVATIVE HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY | Santen Pharmaceutical Co., Ltd (JP) | 2008-11-26 | — | — | EP | disclosed |