Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 10/20 | 0.48 |
| ▸ | SLC19A1 | P41440 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TLR4 | O00206 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TYMS | P04818 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | FOLR2 | P14207 | 1/20 | 0.47 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | GART | P22102 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13187185 | 0.91 | DHFR (0.59) | DHFRSLC19A1KDM4ETLR4MEN1 | |
| SCHEMBL10379252 | 0.87 | DHFR (0.59) | DHFRSLC19A1KDM4ETLR4MEN1 | |
| SCHEMBL13186954 | 0.82 | DHFR (0.59) | DHFRSLC19A1KDM4ETLR4MEN1 | |
| SCHEMBL480317 | 0.82 | DHFR (0.59) | DHFRSLC19A1KDM4ETLR4MEN1 | |
| SCHEMBL18250751 | 0.81 | DHFR (0.59) | DHFRSLC19A1KDM4ETLR4MEN1 | |
| SCHEMBL221621 | 0.78 | DHFR (0.71) | DHFRSLC19A1KDM4ETLR4MEN1 | |
| SCHEMBL29658170 | 0.78 | DHFR (0.71) | DHFRSLC19A1KDM4ETLR4MEN1 | |
| Hydrochloric Acid SCHEMBL1230259 | 0.77 | DHFR (0.70) | DHFRSLC19A1KDM4ETLR4MEN1 | |
| Hydrochloric Acid SCHEMBL3171572 | 0.76 | DHFR (0.69) | DHFRSLC19A1KDM4ETLR4MEN1 | |
| SCHEMBL13187514 | 0.75 | DHFR (0.53) | DHFRSLC19A1KDM4ETLR4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120283219-A1 | DIAMINOPTERIDINE DERIVATIVES | BIORELIX, INC. | 2012-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120283219-A1 | DIAMINOPTERIDINE DERIVATIVES | MPO, AOC1, DCTD | DHFR 19/4885SLC19A1 1532/4885KDM4E 3886/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.