Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.75 |
| ▸ | SHBG | P04278 | 1/20 | 0.75 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.75 |
| ▸ | LMNA | P02545 | 6/20 | 0.62 |
| ▸ | MAPT | P10636 | 5/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | HTT | P42858 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.54 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13966006 | 0.93 | ESR1 (0.64) | ESR1SHBGESR2LMNAMAPT | |
| SCHEMBL38652384 | 0.90 | ESR1 (0.81) | ESR1SHBGESR2LMNAMAPT | |
| SCHEMBL3820741 | 0.90 | ESR1 (0.81) | ESR1SHBGESR2LMNAMAPT | |
| SCHEMBL17637167 | 0.87 | LMNA (0.72) | ESR1SHBGESR2LMNAMAPT | |
| SCHEMBL30503014 | 0.86 | ESR1 (1.00) | ESR1SHBGESR2LMNAMAPT | |
| SCHEMBL312243 | 0.86 | ESR1 (1.00) | ESR1SHBGESR2LMNAMAPT | |
| SCHEMBL9474352 | 0.83 | ALOX5 (0.74) | ESR1SHBGESR2LMNAMAPT | |
| SCHEMBL38652442 | 0.81 | NPC1 (0.76) | ESR1SHBGESR2LMNAMAPT | |
| SCHEMBL3817844 | 0.81 | NPC1 (0.76) | ESR1SHBGESR2LMNAMAPT | |
| SCHEMBL4731182 | 0.81 | NPC1 (0.86) | ESR1SHBGESR2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8742141-B2 | Inhibition and treatment of prostate cancer metastasis | NORTHWESTERN UNIVERSITY (US) | 2014-06-03 | — | — | US | disclosed |
| US-20130296582-A1 | INHIBITION AND TREATMENT OF PROSTATE CANCER METASTASIS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-11-07 | — | — | US | disclosed |
| US-20120283313-A1 | INHIBITION AND TREATMENT OF PROSTATE CANCER METASTASIS | NORTHWESTERN UNIVERSITY (US) | 2012-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130296582-A1 | INHIBITION AND TREATMENT OF PROSTATE CANCER METASTASIS | MAPK4, MAP4K4, MAP3K4 | ESR1 872/4885SHBG 2937/4885ESR2 1564/4885 |
| US-20120283313-A1 | INHIBITION AND TREATMENT OF PROSTATE CANCER METASTASIS | MAPK4, MAP4K4, MAP3K4 | ESR1 872/4885SHBG 2937/4885ESR2 1564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.