Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 4/20 | 0.47 |
| ▸ | ACHE | P22303 | 4/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL439635 | 0.81 | APP (0.48) | KDM4EAPPBCHEACHECHRM1 | |
| SCHEMBL440060 | 0.81 | BCHE (0.50) | KDM4EAPPBCHEACHECHRM1 | |
| SCHEMBL436681 | 0.79 | LMNA (0.63) | KDM4EAPPBCHEACHECHRM1 | |
| SCHEMBL2010360 | 0.78 | LMNA (0.44) | KDM4ELMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL28160334 | 0.77 | HTR1A (0.45) | KDM4EAPPBCHEACHECHRM1 | |
| SCHEMBL2014648 | 0.77 | ERN1 (0.56) | KDM4ELMNAALDH1A1MAPTMEN1 | |
| SCHEMBL2011169 | 0.77 | LMNA (0.57) | KDM4ELMNAALDH1A1MAPTGAA | |
| SCHEMBL2012625 | 0.76 | PLA2G2A (0.50) | KDM4ELMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL27888615 | 0.75 | ALDH1A1 (0.58) | KDM4ELMNAALDH1A1MAPK1NPSR1 | |
| SCHEMBL591852 | 0.75 | LMNA (0.62) | KDM4ELMNAMAPTHTR1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009125809-A1 | PIPERIDINE DERIVATIVES | 第一三共株式会社 (JP) | 2009-10-15 | — | — | WO | disclosed |
| WO-2009125808-A1 | AMINOCYCLOHEXYL DERIVATIVE | 第一三共株式会社 (JP) | 2009-10-15 | — | — | WO | disclosed |