SCHEMBL13655212

SCHEMBL13655212

CN(C)Cc1cccc(C2CN=C(N)N2)c1

nearest known ligand 0.38

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
NOS1 P29475 5/20 0.38
PARP1 P09874 3/20 0.38
MGMT P16455 1/20 0.38
HTR7 P34969 1/20 0.36
ALDH1A1 P00352 1/20 0.36
TSHR P16473 1/20 0.36
NOS2 P35228 2/20 0.35
ATP4A P20648 2/20 0.35
ATP4B P51164 2/20 0.35
CHRNB2 P17787 1/20 0.34
CHRNA4 P43681 1/20 0.34
HPGD P15428 1/20 0.32
LCK P06239 1/20 0.32
ITK Q08881 1/20 0.32
GRIN2B Q13224 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17887717 0.73 NOS1 (0.41) NOS1NOS2
SCHEMBL8219698 0.71 CHRNA7 (0.45) NOS1HTR7ALDH1A1TSHRCHRNB2
SCHEMBL23278119 0.71 ALDH1A1 (0.47) NOS1HTR7ALDH1A1TSHRCHRNB2
SCHEMBL25320228 0.70 ALDH1A1 (0.37) NOS1PARP1HTR7ALDH1A1TSHR
SCHEMBL13655362 0.68 CHRNB2 (0.51) CHRNB2CHRNA4
SCHEMBL989636 0.67 ALDH1A1 (0.67) NOS1HTR7ALDH1A1TSHRCHRNB2
SCHEMBL309116 0.66 ALDH1A1 (0.54) NOS1HTR7ALDH1A1TSHRNOS2
SCHEMBL8844212 0.66 HTR2C (0.46)
Hydrochloric Acid SCHEMBL5913208 0.65 MAOA (0.53) NOS1HTR7ALDH1A1TSHRNOS2
Hydrochloric Acid SCHEMBL3863134 0.65 MAOA (0.53) NOS1HTR7ALDH1A1TSHRNOS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009123753-A1 INHIBITION OF BACTERIAL BIOFILMS WITH IMIDAZOLE-PHENYL DERIVATIVES NORTH CAROLINA STATE UNIVERSITY (US) 2009-10-08 WO disclosed